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The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy
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SYSNO ASEP 0349092 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The causes of cancer revisited: "Mitochondrial malignancy" and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy Tvůrce(i) Ralph, S.J. (AU)
Rodruguez-Enriquez, S. (MX)
Neužil, Jiří (BTO-N) RID
Saavedra, E. (MX)
Moreno-Sanchez, R. (MX)Zdroj.dok. Molecular Aspects of Medicine. - : Elsevier - ISSN 0098-2997
Roč. 31, č. 2 (2010), s. 145-170Poč.str. 25 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Carcinogenesis ; mitocans ; hypoxia Vědní obor RIV FD - Onkologie a hematologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000277919600003 DOI 10.1016/j.mam.2010.02.008 Anotace The review is organized into five sections concerning different aspects of "mitochondrial malignancy". The first concerns the functions of mitochondrial ROS and its importance as a pacesetter for cell growth versus senescence and death. The second considers the available evidence that cellular stress in the form of hypoxic and/or hypoglycaemic conditions represent two major triggering events for cancer and how oncoproteins reinforce this process. The third presents evidence that oncoproteins and tumor suppressor proteins physically localize to the mitochondria in cancer cells where they directly regulate malignant mitochondrial programs, including apoptosis. The fourth covers mutational changes in the mitochondrial genome as they relate to malignancy and to the other three areas. The last section concerns the relevance of these findings and their importance for novel approaches to anti-cancer therapy and selective triggering in cancer cells of the mitochondrial apoptotic pathway. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2011
Počet záznamů: 1