Počet záznamů: 1  

Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis

  1. 1.
    SYSNO ASEP0348119
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevInflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis
    Tvůrce(i) Dunne, A. (IE)
    Ross, P. J. (IE)
    Pospíšilová, Eva (MBU-M)
    Mašín, Jiří (MBU-M) RID
    Meaney, A. (IE)
    Sutton, C. E. (IE)
    Iwakura, Y. (JP)
    Tschopp, J. (CH)
    Šebo, Peter (MBU-M) RID
    Mills, K. H. G. (IE)
    Zdroj.dok.Journal of Immunology - ISSN 0022-1767
    Roč. 187, č. 3 (2010), s. 1711-1719
    Poč.str.9 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaADAPTIVE IMMUNE-RESPONSES ; IL-17-PRODUCING T-CELLS ; HOST-DEFENSE
    Vědní obor RIVEC - Imunologie
    CEPGA310/08/0447 GA ČR - Grantová agentura ČR
    IAA500200914 GA AV ČR - Akademie věd
    CEZAV0Z50200510 - MBU-M (2005-2011)
    UT WOS000280177400048
    DOI10.4049/jimmunol.1000105
    AnotaceIn this article, we demonstrate that inflammasome-mediated IL-1b plays a critical role in promoting Ag-specific Th17 cells and in generating protective immunity against Bordetella pertussis infection. Using a murine respiratory challenge model, we demonstrated that the course of B. pertussis infection was significantly exacerbated in IL-1R type I-defective (IL-1RI2/2) mice. We found that adenylate cyclase toxin (CyaA), a key virulence factor secreted by B. pertussis, induced robust IL-1b production by dendritic cells through activation of caspase-1 and the NALP3-containing inflammasome complex. Using mutant toxins, we demonstrate that CyaA-mediated activation of caspase-1 was not dependent on adenylate cyclase enzyme activity but was dependent on the pore-forming capacity of CyaA
    PracovištěMikrobiologický ústav
    KontaktEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Rok sběru2011