Počet záznamů: 1
N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation
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SYSNO ASEP 0347842 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation Tvůrce(i) Chytil, Petr (UMCH-V) RID, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCID
Kříž, Jaroslav (UMCH-V) RID
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RIDZdroj.dok. European Journal of Pharmaceutical Sciences. - : Elsevier - ISSN 0928-0987
Roč. 41, 3/4 (2010), s. 473-482Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova HPMA copolymers ; drug carriers ; RAFT polymerisation Vědní obor RIV CD - Makromolekulární chemie CEP IAA400500806 GA AV ČR - Akademie věd IAAX00500803 GA AV ČR - Akademie věd CEZ AV0Z40500505 - UMCH-V (2005-2011) UT WOS 000283690000007 DOI 10.1016/j.ejps.2010.08.003 Anotace Controlled RAFT polymerisation was used to prepare polymer–drug carriers based on HPMA copolymers, showing well-defined structure with narrow molecular weight distribution. The anticancer drug doxorubicin was bound to the polymeric carrier by hydrazone bond enabling pH-controlled release. RAFT polymerisation facilitated the synthesis of semitelechelic copolymers, which were used in the synthesis of monoclonal anti-CD20 antibody–polymer–drug conjugate and reductively degradable high-molecular-weight graft polymer–drug conjugate, designed for active or passive tumour targeting. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2011
Počet záznamů: 1