Počet záznamů: 1
Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations
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SYSNO ASEP 0347205 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic structure and contrasting selection pattern at two major histocompatibility complex genes in wild house mouse populations Tvůrce(i) Čížková, Dagmar (UBO-W) RID, SAI, ORCID
Goüy de Bellocq, J. (BE)
Baird, S. J. E. (PT)
Piálek, Jaroslav (UBO-W) RID, ORCID, SAI
Bryja, Josef (UBO-W) RID, SAI, ORCIDCelkový počet autorů 5 Zdroj.dok. Heredity - ISSN 0018-067X
Roč. 106, č. 5 (2011), s. 727-740Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova MHC ; house mouse ; selection ; population structure ; trans-species polymorphism Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA600930608 GA AV ČR - Akademie věd GA206/08/0640 GA ČR - Grantová agentura ČR CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000289713700005 EID SCOPUS 79955099391 DOI 10.1038/hdy.2010.112 Anotace The mammalian major histocompatibility complex (MHC) is a tightly linked cluster of immune genes, and is often thought of as inherited as a unit. This has led to the hope that studying a single MHC gene will reveal patterns of evolution representative of the MHC as a whole. In this study we analyse a 1000-km transect of MHC variation in house mice to compare signals of selection and patterns of diversification at two closely linked MHC class II genes, H-2Aa and H-2Eb. We show that although they are 0.01cM apart, disparate evolutionary patterns were detected. H-2Aa shows higher allelic polymorphism, faster allelic turnover due to higher mutation rates, stronger positive selection at antigen-binding sites and higher population structuring than H-2Eb. H-2Eb alleles are maintained in the gene pool for longer, including over separation of the subspecies, some H-2Eb alleles are positively and others negatively selected and some of the alleles are not expressed. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2012
Počet záznamů: 1