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Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling
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SYSNO ASEP 0347149 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling Tvůrce(i) Blažková, Hana (UMG-J)
Krejčíková, Kateřina (UMG-J)
Moudrý, Pavel (UMG-J)
Frisan, T. (SE)
Hodný, Zdeněk (UMG-J) RID
Bártek, Jiří (UMG-J) RIDZdroj.dok. Journal of Cellular and Molecular Medicine. - : Wiley - ISSN 1582-1838
Roč. 14, 1-2 (2009), s. 357-367Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cellular senescence ; DNA damage response ; bacterial toxins Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500390501 GA AV ČR - Akademie věd GA204/08/1418 GA ČR - Grantová agentura ČR GA301/08/0353 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000275639700031 DOI 10.1111/j.1582-4934.2009.00862.x Anotace Cytolethal distending toxins (CDT) are proteins produced and secreted by facultative pathogenic strains of gram-negative bacteria with potentially genotoxic effects. We found both normal and cancer human cells exposed to CDT, surviving the acute phase of intoxication by Haemophilus ducreyi CDT, possess the main hallmarks of cellular senescence including persistently activated DNA damage signalling, expansion of promyelocytic leukaemia nuclear compartment and induced expression of several cytokines (e.g. IL-6, IL-8 and IL-24). We conclude that analogous to oncogenic, oxidative and replicative stresses, bacterial toxins represent another pathophysiological stimulus that induces premature senescence. Thus, the activation of cellular senescence as the anticancer barrier, together with evidence of chromosomal defects reported here, support the emerging genotoxic and potentially oncogenic effects of this group of bacterial toxins, and warrant further research of their role in human disease. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
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