Počet záznamů: 1

Heterochromatin marks HP1gamma, HP1alpha and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours

SYSNO ASEP	0347140
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Heterochromatin marks HP1gamma, HP1alpha and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours
Tvůrce(i)	Bartkova, J. (DK) Moudrý, Pavel (UMG-J) Hodný, Zdeněk (UMG-J)_RID Lukas, J. (DK) Rajpert-De Meyts, E. (DK) Bártek, Jiří (UMG-J)_RID
Zdroj.dok.	International Journal of Andrology. - : WILEY-BLACKWELL - ISSN 0105-6263 Roč. 34, 4 Pt 2 (2011), e103-e113
Poč.str.	11 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	heterochromatinization ; DNA damage response ; germinal tumours
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA301/08/0353 GA ČR - Grantová agentura ČR
CEZ	AV0Z50520514 - UMG-J (2005-2011)
UT WOS	000293174100013
DOI	10.1111/j.1365-2605.2010.01096.x
Anotace	Heterochromatinization has been implicated in fundamental biological and pathological processes including differentiation, senescence, ageing and tumorigenesis; however, little is known about its regulation and roles in human cells and tissues in vivo. Here, we show distinct cell-type- and cancer-stage-associated patterns of key heterochromatin marks: histone H3 trimethylated at lysine 9 (H3K9me3) and heterochromatic adaptor proteins HP1α and HP1γ, compared with the γH2AX marker of endogenously activated DNA damage response (DDR) and proliferation markers in normal human foetal and adult testes, pre-invasive carcinoma in situ (CIS) lesions and a series of overt germ cell tumours, including seminomas, embryonal carcinomas and teratomas. Among striking findings were high levels of HP1γ in foetal gonocytes, CIS and seminomas; enhanced multimarker heterochromatinization without DDR activation in CIS; and enhanced HP1α in teratoma structures with epithelial and neuronal differentiation.
Pracoviště	Ústav molekulární genetiky
Kontakt	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Rok sběru	2012

Počet záznamů: 1