Počet záznamů: 1
Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm
- 1.
SYSNO ASEP 0347001 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm Tvůrce(i) Machoň, Ondřej (UMG-J) RID
Krešlová, Jana (UMG-J)
Růžičková, Jana (UMG-J)
Vacík, Tomáš (UMG-J) RID
Klímová, Lucie (UMG-J)
Fujimura, Naoko (UMG-J)
Láchová, Jitka (UMG-J)
Kozmik, Zbyněk (UMG-J) RIDZdroj.dok. Genesis - ISSN 1526-954X
Roč. 48, č. 2 (2010), s. 86-95Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Wnt, Pax6 ; lens ; eye Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/08/1618 GA ČR - Grantová agentura ČR 1M0520 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000274719500002 DOI 10.1002/dvg.20583 Anotace Lens formation in mouse is critically dependent on proper development of the retinal neuroectoderm that is located close beneath the head surface ectoderm. Signaling from the prospective retina triggers lens-specific gene expression in the surface-ectoderm. Supression of canonical Wnt/β-catenin signaling in the surface ectoderm is one of the prerequisites for lens development because, as we show here, ectopic Wnt activation in the retina and lens abrogates lens formation. Wnt inhibiton is mediated by signals coming from the retina but its exact mechanism is unknown. We show that Pax6 directly controls expression of several Wnt inhibitors such as Sfrp1, Sfrp2, and Dkk1 in the presumptive lens. In accordance, absence of Pax6 function leads to aberrant canonical Wnt activity in the presumptive lens that subsequently impairs lens development. Thus Pax6 is required for down-regulation of canonical Wnt signaling in the presumptive lens ectoderm. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
Počet záznamů: 1