Počet záznamů: 1

P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes

  1. 1.
    SYSNO ASEP0346838
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    NázevP-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes
    Tvůrce(i)Flemr, Matyáš (UMG-J) - Ma, J. (US) - Schultz, R. M. (US) - Svoboda, Petr (UMG-J)
    Rozsah stran1008 - 1017
    Zdroj.dok.Biology of Reproduction - ISSN 0006-3363
    Poč.str.10 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaoocyte ; mRNA ; cortex
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEPME09039 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    CEZAV0Z50520514 - UMG-J (2005-2011)
    UTISI000276867800023
    DOI10.1095/biolreprod.109.082057
    AnotaceP-bodies are centers of mRNA metabolism, where meet pathways linked to mRNA silencing and degradation. So far, P-bodies were found in all examined mammalian cells.Here, we show an unexpected and important discovery that P-bodies disappear from oocztes at the beginning of their growth phase and appear again only in the early embryo. P-body decay likely reflects the requirement stabiliyation and storage of maternal mRNAs, which will govern development until the zygotc expression takes over. In addition, we were the first to show that stored maternal mRNAs do not have a homogeneous distribution. Instead, they localize to the periphery – cortex.
    PracovištěÚstav molekulární genetiky
    KontaktGabriela Marešová, maresova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2011