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A new type of membrane raft-like microdomains and their possible involvement in TCR signaling
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SYSNO ASEP 0346793 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název A new type of membrane raft-like microdomains and their possible involvement in TCR signaling Tvůrce(i) Otáhal, Pavel (UMG-J) RID
Angelisová, Pavla (UMG-J) RID
Hrdinka, Matouš (UMG-J)
Brdička, Tomáš (UMG-J) RID
Novák, Petr (MBU-M) RID, ORCID
Drbal, Karel (UMG-J)
Hořejší, Václav (UMG-J) RIDZdroj.dok. Journal of Immunology. - : American Association of Immunologists - ISSN 0022-1767
Roč. 184, č. 7 (2010), s. 3689-3696Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova membrane rafts ; LAT ; T-receptor Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000275927600047 DOI 10.4049/jimmunol.0902075 Anotace One of the key signaling molecules present in T cell detergent-resistant membrane domains (DRMs) derived from membrane rafts is the transmembrane adaptor protein LAT (linker for activation of T cells). In contrast to previous results, a recent study demonstrated that a LAT construct not present in the buoyant DRMs is fully able to support TCR signaling and development of T cells in vivo. This finding caused doubts about the real physiological role of rafts in TCR signaling. In this study, we demonstrate that these results can be explained by the existence of a novel type of membrane raft-like microdomains, containing a number of membrane molecules. At a moderate level of expression, LAT supported TCR signaling more efficiently than constructs targeted to the microdomains producing heavy DRMs or to nonraft membrane. We suggest that different types of membrane microdomains provide environments regulating the functional efficiencies of signaling molecules present therein. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2011
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