Počet záznamů: 1
Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro
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SYSNO ASEP 0346777 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro Tvůrce(i) Čtrnáctá, Vlasta (BTO-N) RID
Fritzler, J. M. (US)
Šurínová, M. (CZ)
Hrdý, I. (CZ)
Zhu, G. (US)
Stejskal, F. (CZ)Zdroj.dok. Experimental Parasitology. - : Elsevier - ISSN 0014-4894
Roč. 126, č. 2 (2010), s. 113-116Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova S-adenosylhomocysteine hydrolase ; D-eritadenine ; (S)-DHPA Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000280885500001 DOI 10.1016/j.exppara.2010.04.007 Anotace D-eritadenine and (S)-DHPA are aliphatic adenosine analogues known to target S-adenosylhomocysteine hydrolase (SAHH) and potent antiviral compounds. In the present study, we demonstrate that these two compounds also display efficacy against recombinant SAHH enzyme of the protozoan parasite Cryptosporidium parvum, as well as inhibition of parasite growth in vitro. Our data confirm that SAHH could serve as a rational drug target in cryptosporidial infection and antiviral adenosine analogues are potential candidates for drug development against cryptosporidiosis Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2011
Počet záznamů: 1