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The chicken Z chromosome is enriched for genes with preferential expression in ovarian somatic cells
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SYSNO ASEP 0346754 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The chicken Z chromosome is enriched for genes with preferential expression in ovarian somatic cells Tvůrce(i) Mořkovský, L. (CZ)
Storchová, R. (CZ)
Plachý, Jiří (UMG-J) RID
Ivánek, Robert (UMG-J)
Divina, Petr (UMG-J)
Hejnar, Jiří (UMG-J) RIDZdroj.dok. Journal of Molecular Evolution - ISSN 0022-2844
Roč. 70, č. 2 (2010), s. 129-136Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Z chromosome ; meiotic sex chromosome inactivation ; sexual antagonisms Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000274746600001 DOI 10.1007/s00239-009-9315-5 Anotace Over- or under-representation of sexually antagonistic mutations on avian X and Z chromosomes depends, in theory, on their average dominance coefficients. These coefficients, however, remain to be characterized. To elucidate the role of sexually antagonistic selection in the evolution of Z chromosome gene content in chicken, we analyzed publicly available microarray data from several somatic tissues as well as somatic and germ cells of the ovary. We found that the Z chromosome is enriched for genes showing preferential expression in ovarian somatic cells, but not for genes with preferential expression in primary oocytes or non-sex-specific somatic tissues. Our results suggest that sexual antagonism leads to higher abundance of female-benefit alleles on the Z chromosome. Our results are consistent with findings in mammals and indicate that recessive rather than dominant sexually antagonistic mutations shape the gene content of the X and Z chromosomes. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
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