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Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering
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SYSNO ASEP 0345865 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering Tvůrce(i) Studenovská, Hana (UMCH-V) RID, ORCID
Vodička, Petr (UZFG-Y) ORCID
Proks, Vladimír (UMCH-V) RID, ORCID
Hlučilová, Jana (UZFG-Y) RID, ORCID
Motlík, Jan (UZFG-Y) RID, ORCID
Rypáček, František (UMCH-V) RIDZdroj.dok. Journal of Tissue Engineering and Regenerative Medicine. - : Wiley - ISSN 1932-6254
Roč. 4, č. 6 (2010), s. 454-463Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova polyamino acid ; hydrogel ; porosity Vědní obor RIV CD - Makromolekulární chemie CEP KJB400500801 GA AV ČR - Akademie věd 1M0538 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z40500505 - UMCH-V (2005-2011) AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000281152400005 DOI 10.1002/term.256 Anotace Preparation of soft poly(amino acid) hydrogels containing biomimetic cell-adhesive peptides was investigated. Covalently crosslinked gels were formed by radical co-polymerization of methacryloylated macromonomer poly[N5-(2-hydroxyethyl)-L-glutamine-stat-L-alanine-stat-methacryloyllysine] with 2-hydroxyethyl methacrylate (HEMA) as minor co-monomer. Hydrogels carrying biomimetic peptides were prepared by using methacryloylated peptides, such as methacryloyl-GGGRGDSG-OH and methacryloyl-GGGYIGSR-OH, as additional monomers in the polymerization mixture. While unmodified hydrogels showed very low cell adhesion, due to their highly hydrophilic nature, the incorporation of adhesive peptides significantly improved the adhesion and viability of seeded cells. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2011
Počet záznamů: 1