Počet záznamů: 1  

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

  1. 1.
    SYSNO ASEP0345709
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevAnimals lacking link protein have attenuated perineuronal nets and persistent plasticity
    Tvůrce(i) Carulli, D. (GB)
    Pizzorusso, T. (IT)
    Kwok, J. C. F. (GB)
    Putignano, E. (IT)
    Poli, A. (IT)
    Forostyak, Serhiy (UEM-P) RID, ORCID
    Andrews, M. R. (GB)
    Deepa, S. S. (GB)
    Glant, T. (US)
    Fawcett, J. W. (GB)
    Zdroj.dok.Brain - ISSN 0006-8950
    Roč. 133, č. 8 (2010), s. 2331-2347
    Poč.str.17 s.
    Jazyk dok.eng - angličtina
    Země vyd.GB - Velká Británie
    Klíč. slovaplasticity ; ocular dominance ; extracellular matrix
    Vědní obor RIVFH - Neurologie, neurochirurgie, neurovědy
    CEZAV0Z50390703 - UEM-P (2007-2013)
    UT WOS000280982700015
    DOI10.1093/brain/awq145
    AnotaceChondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. In this article has been measured the changes in the CSPGs that occur during the critical period in rats and mice. The molecular event that triggers PNN formation has been identified, showing that the PNN component cartilage link protein Crtl1 (Hapln1) is up-regulated as the structures form. In keeping with the hypothesis that PNN maturation down-regulates plasticity, we found that adult plasticity in the visual and somatosensory systems of mice lacking Crtl1 was strongly enhanced. Overall, our findings demonstrate that the formation of PNNs triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS and suggest that modification of PNNs is how CSPGs reactivate plasticity.
    PracovištěÚstav experimentální medicíny
    KontaktLenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
    Rok sběru2011
Počet záznamů: 1  

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