Počet záznamů: 1
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
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SYSNO ASEP 0345709 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Animals lacking link protein have attenuated perineuronal nets and persistent plasticity Tvůrce(i) Carulli, D. (GB)
Pizzorusso, T. (IT)
Kwok, J. C. F. (GB)
Putignano, E. (IT)
Poli, A. (IT)
Forostyak, Serhiy (UEM-P) RID, ORCID
Andrews, M. R. (GB)
Deepa, S. S. (GB)
Glant, T. (US)
Fawcett, J. W. (GB)Zdroj.dok. Brain - ISSN 0006-8950
Roč. 133, č. 8 (2010), s. 2331-2347Poč.str. 17 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova plasticity ; ocular dominance ; extracellular matrix Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000280982700015 DOI 10.1093/brain/awq145 Anotace Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult central nervous system and their digestion with chondroitinase reactivates plasticity. In this article has been measured the changes in the CSPGs that occur during the critical period in rats and mice. The molecular event that triggers PNN formation has been identified, showing that the PNN component cartilage link protein Crtl1 (Hapln1) is up-regulated as the structures form. In keeping with the hypothesis that PNN maturation down-regulates plasticity, we found that adult plasticity in the visual and somatosensory systems of mice lacking Crtl1 was strongly enhanced. Overall, our findings demonstrate that the formation of PNNs triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS and suggest that modification of PNNs is how CSPGs reactivate plasticity. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2011
Počet záznamů: 1