Počet záznamů: 1
Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats
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SYSNO ASEP 0345610 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats Tvůrce(i) Matějů, Kristýna (FGU-C)
Sumová, Alena (FGU-C) RID, ORCID
Bendová, Zdeňka (FGU-C)Zdroj.dok. Journal of Comparative Neurology. - : Wiley - ISSN 0021-9967
Roč. 518, č. 17 (2010), s. 3630-3644Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova development ; retina ; circadian clock Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP GA309/08/0503 GA ČR - Grantová agentura ČR LC554 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000280311700013 DOI 10.1002/cne.22421 Anotace The aim of the study was to elucidate whether, when and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn retina. Endogenous expression of Per1 was detected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from postnatal day 1 (P1). Light pulses also induced the expression of Per1 and c-fos in the retinal pigment epithelium until P3, but not afterward. Expression of Per2 was not photoresponsive until P10. The data demonstrate that the rat retina is photosensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2011
Počet záznamů: 1