Počet záznamů: 1
Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat
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SYSNO ASEP 0344049 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat Tvůrce(i) Jirout, M. L. (US)
Friese, R. S. (US)
Mahapatra, N. R. (US)
Mahata, M. (US)
Taupenot, L. (US)
Mahata, S. K. (US)
Křen, V. (CZ)
Zídek, Václav (FGU-C) RID
Fischer, J. (DE)
Maatz, H. (DE)
Ziegler, M. G. (US)
Pravenec, Michal (FGU-C) RID, ORCID
Hubner, N. (DE)
Aitman, T. J. (GB)
Schork, N. J. (US)
O´Connor, D. T. (US)Zdroj.dok. Human Molecular Genetics. - : Oxford University Press - ISSN 0964-6906
Roč. 19, č. 13 (2010), s. 2567-2580Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova spontaneously hypertensive rat ; catecholamines ; blood pressure Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500110604 GA AV ČR - Akademie věd CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000279674200003 DOI 10.1093/hmg/ddq135 Anotace We identified cis-acting eQTLs for Dbh, Pnmt (catecholamine biosynthesis) and Vamp1 (catecholamine secretion); enzymatic activities of Dbh and Pnmt paralleled transcripts, with pQTLs for activities mirroring eQTLs. We also detected trans-regulated expression of Vmat1 and Chga (both involved in catecholamine storage), with co-localization of these trans-eQTLs to the Pnmt locus. The finding of such cis- and trans-QTLs at an age before the onset of frank hypertension suggests that these heritable changes in biosynthetic enzyme expression represent primary genetic mechanisms for regulation of catecholamine action and blood pressure control in this widely studied model of hypertension Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2011
Počet záznamů: 1