Počet záznamů: 1
Para-hydrogenated Glucose Derivatives as Potential 13C-Hyperpolarized Probes for Magnetic Resonance Imaging
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SYSNO ASEP 0343958 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Para-hydrogenated Glucose Derivatives as Potential 13C-Hyperpolarized Probes for Magnetic Resonance Imaging Tvůrce(i) Reineri, F. (IT)
Santelia, D. (IT)
Viale, A. (IT)
Cerutti, E. (IT)
Poggi, L. (IT)
Tichý, Tomáš (UOCHB-X) RID
Premkumar, S. S. D. (IT)
Gobetto, R. (IT)
Aime, S. (IT)Celkový počet autorů 9 Zdroj.dok. Journal of the American Chemical Society. - : American Chemical Society - ISSN 0002-7863
Roč. 132, č. 20 (2010), s. 7186-7193Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova magnetic resonance imaging ; para-hydrogen-induced polarization ; glucose Vědní obor RIV CC - Organická chemie CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000277999700058 DOI 10.1021/ja101399q Anotace A set of molecules in which a glucose moiety is bound to a hydrogenable synthon has been synthesized and evaluated for hydrogenation reactions and for the corresponding PHIP effects, in order to select suitable candidates for an in vivo MRI method for the assessment of glucose cellular uptake. It has been found that amidic derivatives do not yield any polarization enhancement. In contrast, ester derivatives are hydrogenated in high yield and afford enhanced 1H and 13C NMR spectra after para-hydrogenation. These molecules may find interesting applications in 13C MRI as hyperpolarized probes for assessing the activity of glucose transporters in cells. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2011
Počet záznamů: 1