Počet záznamů: 1  

Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study

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    SYSNO ASEP0343468
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevExpression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
    Tvůrce(i) Vrajová, M. (CZ)
    Šťastný, František (FGU-C)
    Horáček, J. (CZ)
    Lochman, J. (CZ)
    Šerý, O. (CZ)
    Peková, S. (CZ)
    Klaschka, Jan (UIVT-O) RID, SAI, ORCID
    Höschl, C. (CZ)
    Zdroj.dok.Neurochemical Research - ISSN 0364-3190
    Roč. 35, č. 7 (2010), s. 994-1002
    Poč.str.9 s.
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovaschizophrenia ; hippocampus ; GluN1 subunit of NMDA receptor ; splice variants ; laterality
    Vědní obor RIVFL - Psychiatrie, sexuologie
    CEZAV0Z50110509 - FGU-C (2005-2011)
    AV0Z10300504 - UIVT-O (2005-2011)
    UT WOS000278411000005
    EID SCOPUS77953231677
    DOI10.1007/s11064-010-0145-z
    AnotaceThere is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients.
    PracovištěÚstav informatiky
    KontaktTereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800
    Rok sběru2011