Počet záznamů: 1
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
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SYSNO ASEP 0343342 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin Tvůrce(i) Pintérová, Mária (FGU-C)
Karen, Petr (FGU-C)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Zicha, Josef (FGU-C) RID, ORCID, SAIZdroj.dok. Journal of Hypertension. - : Lippincott Williams & Wilkins - ISSN 0263-6352
Roč. 28, č. 5 (2010), s. 969-978Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova calcium channels ; inhibitory G proteins ; pertussis toxin Vědní obor RIV FA - Kardiovaskulární nemoci vč. kardiochirurgie CEP 1M0510 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA305/08/0139 GA ČR - Grantová agentura ČR IAA500110902 GA AV ČR - Akademie věd CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000276706500015 DOI 10.1097/HJH.0b013e328335dd49 Anotace The overexpression of pertussis toxin (PTX)-sensitive inhibitory G-proteins (Gi) participating in the development and maintenance of high BP in SHRs suggested us to study Gi-protein involvement in the pathway through which noradrenergic vasoconstriction and calcium influx can be coupled. PTX pretreatment of SHRs significantly decreased BP and reduced sympathetic vasoconstriction, which was partially substituted by enhanced angiotensin II-dependent vasoconstriction. PTX pretreatment of SHRs also decreased BP component sensitive to acute blockade of calcium entry by nifedipine. Thus the enhanced contribution of SNS to hypertension maintenance in SHRs is mediated by Gi-protein-coupled pathway controlling calcium influx through L type of voltage-dependent calcium channels Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2011
Počet záznamů: 1