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Novel Nucleophilic Compounds with Oxime Group as Reactivators of Paraoxon-Inhibited Cholinesterases
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SYSNO ASEP 0342827 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Novel Nucleophilic Compounds with Oxime Group as Reactivators of Paraoxon-Inhibited Cholinesterases Tvůrce(i) Musilová, L. (CZ)
Jun, D. (CZ)
Paleček, J. (DE)
Církva, Vladimír (UCHP-M) RID, ORCID, SAI
Musílek, K. (CZ)
Paar, M. (CZ)
Hrabinová, M. (CZ)
Pohanka, M. (CZ)
Kuca, K. (CZ)Zdroj.dok. Letters in Drug Design & Discovery - ISSN 1570-1808
Roč. 7, č. 4 (2010), s. 260-264Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova acetylcholinesterase ; butyrylcholinesterase ; nerve agent Vědní obor RIV CC - Organická chemie CEZ AV0Z40720504 - UCHP-M (2005-2011) UT WOS 000275929300006 DOI 10.2174/157018010790945823 Anotace New cholinesterase reactivators are synthesized as potential antidotes for treatment of organophosphorus agent poisonings or as part of pseudo catalytic scavengers for improvement of the nerve agent prophylaxis. In this study, three novel potential cholinesterase reactivators (K064 - (E)-1-(pyridinium)-4-(2-hydroxyiminomethylpyridinium)-but-2-ene dibromide; K065 - (E)-1-(quinolinium)-4-(2-hydroxyiminomethylpyridinium)-but-2-ene dibromide; K066 - (E)-1-(isoquinolinium)-4-(2-hydroxyiminomethylpyridinium)-but-2-ene dibromide) were synthesized and tested for their potency to reactivate acetylcholinesterase (AChE, EC 3.1.1.3) and butyrylcholinesterase (BChE, 3.1.1.8) inhibited by pesticide paraoxon. As resulted, none from the synthesized compounds surpassed currently clinically used reactivators (pralidoxime, obidoxime and HI-6). Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2011
Počet záznamů: 1