Počet záznamů: 1

Functional analysis of the skin-swelling response to phytohaemagglutinin

SYSNO ASEP	0342466
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Functional analysis of the skin-swelling response to phytohaemagglutinin
Tvůrce(i)	Vinkler, Michal (UBO-W)_{RID, ORCID} Bainová, H. (CZ) Albrecht, Tomáš (UBO-W)_{RID, SAI, ORCID}
Celkový počet autorů	3
Zdroj.dok.	Functional Ecology. - : Wiley - ISSN 0269-8463 Roč. 24, č. 5 (2010), s. 1081-1086
Poč.str.	6 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	avian innate and adaptive immunity ; ecoimmunology ; ecological immunology ; ecotoxicology ; inflammatory response ; PHA-induced hypersensitivity ; phytohaemagglutinin ; T-cell-mediated immunocompetence
Vědní obor RIV	EG - Zoologie
CEP	GA206/08/1281 GA ČR - Grantová agentura ČR
	GA206/08/0640 GA ČR - Grantová agentura ČR
	LC06073 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z60930519 - UBO-W (2005-2011)
UT WOS	000281895800016
EID SCOPUS	78149289134
DOI	10.1111/j.1365-2435.2010.01711.x
Anotace	The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations.
Pracoviště	Ústav biologie obratlovců
Kontakt	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Rok sběru	2011

Počet záznamů: 1