Počet záznamů: 1
Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells
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SYSNO ASEP 0341156 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cell signalling in CNS and immune system in depression and during antidepressant treatment: focus on glial and natural killer cells Tvůrce(i) Kovářu, H. (CZ)
Páv, M. (CZ)
Kovářů, František (UZFG-Y)
Raboch, J. (CZ)
Fišerová, Anna (MBU-M) RIDZdroj.dok. Neuroendocrinology Letters - ISSN 0172-780X
Roč. 30, č. 4 (2009), s. 421-428Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. SE - Švédsko Klíč. slova astrocyte ; cAMP ; depression Vědní obor RIV ED - Fyziologie CEP IAA601680801 GA AV ČR - Akademie věd CEZ AV0Z50450515 - UZFG-Y (2005-2011) AV0Z50200510 - MBU-M (2005-2011) UT WOS 000273879400001 Anotace There is a considerable evidence that inflammatory response and immune system changes are the part of depression. Components of cellular immune system natural killer cells, important effectors of immune surveillance, are sensitive to stress response, and their functions are compromised in depressive subjects. Many lines of evidence also point to the loss of both neuronal and glial plasticity and neurotrophic factor support under chronic stress or in depression. There is an increasing knowledge of the role of astrocytic cells in neuroplastic processes and neurotransmitter metabolism. Alterations in the glial populations are observed in major depressive subjects. Antidepressant treatment is modulating glial signalization cascades, increasing production of neurotrophic molecules, supporting neuroplasticity processes, and also modulating functions of natural killers. At the level of membrane signalling, antidepressants show a direct influence upon G alpha subunit levels in both immune system and CNS. These findings support the view that antidepressants influence activity of natural killer and astrocytic populations, and this could be of importance in the depression etiopathogenesis and/or treatment. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2010
Počet záznamů: 1