Počet záznamů: 1

Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells

SYSNO ASEP	0340714
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells
Tvůrce(i)	Zhao, Y. (CN) Li, R. (CN) Xia, W. (CN) Neužil, Jiří (BTO-N)_RID Lu, Y. (CN) Zhang, H. (CN) Zhao, X. (CN) Zhang, X. (CN) Sun, C. (CN) Wu, K. (CN)
Zdroj.dok.	Cancer letters. - : Elsevier - ISSN 0304-3835 Roč. 288, č. 1 (2010), s. 42-49
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	IE - Irsko
Klíč. slova	Alpha-tocopheryl succinate ; signaling ; apoptosis
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	GA204/08/0811 GA ČR - Grantová agentura ČR
CEZ	AV0Z50520701 - BTO-N (2007-2013)
UT WOS	000274991700006
DOI	10.1016/j.canlet.2009.06.021
Anotace	The underlying mechanisms of alpha-tocopheryl succinate (alpha-TOS)-mediated apoptosis are not understood in detail, although the redox-silent vitamin E analog is a potent apoptogen and anti-cancer agent. The objective of the present study was to investigate whether apoptosis triggered by alpha-TOS in gastric carcinomas cells involves both mitochondria- and death receptor-dependent pathways. alpha-TOS induced apoptosis and mitochondrial permeability transition in a concentration- and time-dependent manner. As a consequence, cytochrome c and the apoptosis-inducing factor were released and caspases were activated. Bax was translocated from the cytosol to mitochondria and Bid was cleaved into its truncated form, tBid. Knocking down Bid by RNAi and Fas antisense oligodeoxynucleotides resulted in a decreased release and cleavage. The results imply that Bid may serve as a critical integrating factor of the death receptor and mitochondrial pathway in alpha-TOS-mediated apoptosis.
Pracoviště	Biotechnologický ústav
Kontakt	Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
Rok sběru	2010

Počet záznamů: 1