Počet záznamů: 1  

Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis

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    SYSNO ASEP0340567
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevCancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis
    Tvůrce(i) Zobalová, Renata (BTO-N) RID
    Stantic, M. (AU)
    Prokopová, Kateřina (BTO-N)
    Dong, L. F. (AU)
    Neužil, Jiří (BTO-N) RID
    Zdroj.dok.Biofactors - ISSN 0951-6433
    Roč. 34, č. 3 (2009), s. 231-235
    Poč.str.5 s.
    Jazyk dok.eng - angličtina
    Země vyd.NL - Nizozemsko
    Klíč. slovaCancer stem cells ; CD 133 ; FLIP
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEPIAA500520702 GA AV ČR - Akademie věd
    GA204/08/0811 GA ČR - Grantová agentura ČR
    CEZAV0Z50520701 - BTO-N (2007-2013)
    UT WOS000270085200007
    DOI10.3233/BIO-2009-1076
    AnotaceIt is increasingly accepted that cancer stem cells (CSCs) are rather resistant to apoptosis to various inducers, including the immunological apoptogen TRAIL. Here we show that cancer cells with high expression of CD 133, a marker that is often associated with CSCs, are resistant to TRAIL-induced apoptosis, compared to their CD133-low counterparts. We show that this resistance can be ascribed to the high expression of FLIP, an inhibitor of the extrinsic apoptotic pathway, in CD133-high cells. Down¬regulation of FLIP by siRNA in CD133-high cells sensitised them to TRAIL killing. Thus, CD133-high cells may be resistant to TRAIL due to high expression of FLIP.
    PracovištěBiotechnologický ústav
    KontaktMonika Kopřivová, koprivom@img.cas.cz, Tel.: 296 443 610
    Rok sběru2010