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Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis
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SYSNO ASEP 0340567 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cancer cells with high expression of CD133 exert FLIP upregulation and resistance to TRAIL-induced apoptosis Tvůrce(i) Zobalová, Renata (BTO-N) RID
Stantic, M. (AU)
Prokopová, Kateřina (BTO-N) ORCID
Dong, L. F. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Biofactors. - : Wiley - ISSN 0951-6433
Roč. 34, č. 3 (2009), s. 231-235Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Cancer stem cells ; CD 133 ; FLIP Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA500520702 GA AV ČR - Akademie věd GA204/08/0811 GA ČR - Grantová agentura ČR CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000270085200007 DOI 10.3233/BIO-2009-1076 Anotace It is increasingly accepted that cancer stem cells (CSCs) are rather resistant to apoptosis to various inducers, including the immunological apoptogen TRAIL. Here we show that cancer cells with high expression of CD 133, a marker that is often associated with CSCs, are resistant to TRAIL-induced apoptosis, compared to their CD133-low counterparts. We show that this resistance can be ascribed to the high expression of FLIP, an inhibitor of the extrinsic apoptotic pathway, in CD133-high cells. Down¬regulation of FLIP by siRNA in CD133-high cells sensitised them to TRAIL killing. Thus, CD133-high cells may be resistant to TRAIL due to high expression of FLIP. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2010
Počet záznamů: 1