Počet záznamů: 1
Handbook of the Neuroscience of Aging
- 1.
SYSNO ASEP 0340083 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Aging: Extracellular Space Tvůrce(i) Syková, Eva (UEM-P) RID Zdroj.dok. Handbook of the Neuroscience of Aging. - New York : Academic Press, 2009 / Hof P. R. - ISBN 978-0-12-374898-0 Rozsah stran s. 19-26 Poč.str. 8 s. Poč.výt. 500 Poč.str.knihy 740 Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Alzheimer's ; Dementia ; Parkinson's Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z50390703 - UEM-P (2007-2013) Anotace Aging, as well as many neurodegenerative diseases, is accompanied by serious cognitive deficits, particularly impaired learning and memory loss. Cognitive decline in old age has been linked to changes in brain anatomy, morphology, volume, and functional deficits. Nervous tissue, particularly in the hippocampus and cortex, is subject to various degenerative processes, including a decrease in the number and efficacy of synapses, neuronal loss, astrogliosis, and changes in extracellular matrix proteins. These and other changes not only affect the efficacy of signal transmission at synapses, but could also affect extrasynaptic (“volume”) transmission, mediated by the diffusion of transmitters Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2010
Počet záznamů: 1