Počet záznamů: 1
Maternal diabetes alters transcriptional programs in the developing embryo
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SYSNO ASEP 0339735 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Maternal diabetes alters transcriptional programs in the developing embryo Tvůrce(i) Pavlínková, Gabriela (BTO-N) RID, ORCID
Salbaum, M. (US)
Kappen, C. (US)Zdroj.dok. BMC Genomics. - : BioMed Central - ISSN 1471-2164
Roč. 10, č. 274 (2009), s. 1-12Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Diabetic embryopathy ; microarray ; hypoxia Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000268753700004 DOI 10.1186/1471-2164-10-274 Anotace Maternal diabetes is a well-known risk factor for birth defects, such as heart defects and neural tube defects. The causative molecular mechanisms in the developing embryo are currently unknown, and the pathogenesis of developmental abnormalities during diabetic pregnancy is not well understood. We here report results from gene expression profiling of exposed embryos from a mouse diabetes model. In comparison to normal embryos at mid-gestation, we find significantly altered gene expression levels in diabetes-exposed embryos. Over 30% of the genes we have identified encode transcription factors and chromatin modifying proteins or components of signaling pathways that impinge on transcription. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2010
Počet záznamů: 1