Počet záznamů: 1
The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors
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SYSNO ASEP 0339447 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název The Postischemic Environment Differentially Impacts Teratoma or Tumor Formation After Transplantation of Human Embryonic Stem Cell-Derived Neural Progenitors Tvůrce(i) Seminatore, CH. (FR)
Polentes, J. (FR)
Ellman, D. (DK)
Kozubenko, Nataliya (UEM-P) RID
Itier, V. (FR)
Tine, S. (FR)
Tritschler, L. (FR)
Brenot, M. (FR)
Guidou, E. (FI)
Blondeau, J. (FR)
Lhuillier, M. (FR)
Bugi, A. (FR)
Aubry, L. (FR)
Jendelová, Pavla (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RID
Perrier, A. L. (FR)
Finsen, B. (DK)
Onteniente, B. (FR)Zdroj.dok. Stroke - ISSN 0039-2499
Roč. 41, č. 1 (2010), s. 153-159Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova brain transplantation ; human embryonic stem cells ; neural differentiation Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000273093400026 DOI 10.1161/STROKEAHA.109.563015 Anotace We have analyzed the relative effects of the stage of differentiation and the postischemic environment on the formation of adverse structures by transplanted differently mature human embryonic stem cell-derived neural progenitors (NPs). The influence of the postischemic environment was limited to graft survival and occurrence of nonneuroectodermal structures after transplantation of very immature NPs. Both effects were lost with differentiation. We identified a particular stage of differentiation characterized in vitro by a rebound of proliferative aktivity that produced highly proliferative grafts susceptible to threaten surrounding host tissues. The effects of the ischemic environment on the formation of teratoma by transplanted NPs are limited to early differentiation stages that will likely not be used for stem cell therapy. In contrast, hyperproliferation observed at later stages of differentiation corresponds to an intrinsic activity that should be monitored to avoid tumorigenesis in vivo. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2010
Počet záznamů: 1