Počet záznamů: 1
Selective Cyclin-Dependent Kinase Inhibitors Discriminating between Cell Cycle and Transcriptional Kinases Future Reality or Utopia?
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SYSNO ASEP 0335863 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Selective Cyclin-Dependent Kinase Inhibitors Discriminating between Cell Cycle and Transcriptional Kinases Future Reality or Utopia? Překlad názvu Selektivní inhibitory CDK rozlišující kinasy regulující buněčný cyklus a transkripci: Realita nebo utopie? Tvůrce(i) Wesierska-Gadek, J. (AT)
Kryštof, Vladimír (UEB-Q) RID, ORCIDZdroj.dok. New York Academy of Sciences. Annals - ISSN 0077-8923
Roč. 1171, - (2009), s. 228-241Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova cell cycle ; CYC202 ; cyclin-dependent kinase Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/08/0511 GA ČR - Grantová agentura ČR CEZ AV0Z50380511 - UEB-Q (2005-2011) UT WOS 000269657300030 DOI 10.1111/j.1749-6632.2009.04726.x Anotace Progression of the cell cycle is controlled by activating and inhibiting cellular factors. The delicate balance between these positive- and negative-acting regulators warrants proper cell cycle progression in normal cells and facilitates cellular response to a variety of stress stimuli. The increased activity of the positive regulators of the cell cycle in cancer cells is frequently accompanied by the loss or inactivation of the inhibitors of cyclin-dependent kinases (CDKs). The supplementation of the cellular CDK inhibitors by the pharmacological counterparts is a very promising therapeutic option. The generated pharmacological inhibitors of CDKs belong to different classes of compounds and display various CDK inhibitory features. In this article the action and specificity of CDK inhibitor roscovitine, belonging to the group of purine analogues, is reviewed and the rationale for dissecting the inhibitory action on cell cycle and transcriptional CDKs is discussed. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2010
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