Počet záznamů: 1

Evolution of the serum resistance-associated SRA gene in African trypanosomes

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    SYSNO ASEP0334919
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    NázevEvolution of the serum resistance-associated SRA gene in African trypanosomes
    Překlad názvuEvoluce genu asociovaného s sra u afrických trypanosom
    Tvůrce(i)Lai, D. H. (CN) - Wang, Q.P. (CN) - Lukeš, Julius (BC-A) - Lun, Z.R. (CN)
    Rozsah stran1275 - 1278
    Zdroj.dok.Chinese Science Bulletin - ISSN 1001-6538
    Poč.str.4 s.
    Jazyk dok.eng - angličtina
    Země vyd.CN - Čína
    Klíč. slovaSRA ; SRAbc ; evolution ; African trypanosomes
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEP2B06129 GA MŠk - Ministerstvo školství, mládeže a tělovýchovy
    CEZAV0Z60220518 - PAU-O, BC-A (2005-2011)
    UTISI000264842600022
    AnotaceSerum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicated that they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the "donor VSG", which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation.
    PracovištěBiologické centrum (od r. 2006)
    KontaktVáclava Lavičková, lavickova@hbu.cas.cz, Tel.: 387 775 889
    Rok sběru2010