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The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine
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SYSNO ASEP 0334401 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine Tvůrce(i) Křížková, J. (CZ)
Burdová, K. (CZ)
Stiborová, M. (CZ)
Křen, Vladimír (MBU-M) RID, ORCID
Hodek, P. (CZ)Zdroj.dok. Interdisciplinary Toxicology - ISSN 1337-6853
Roč. 2, č. 3 (2009), s. 201-204Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. SK - Slovensko Klíč. slova flavonoids ; cytochrome p450 ; small intestine Vědní obor RIV EE - Mikrobiologie, virologie CEP GD305/09/H008 GA ČR - Grantová agentura ČR CEZ AV0Z50200510 - MBU-M (2005-2011) DOI 10.2478/v10102-009-0018-y Anotace Flavonoids, as foreign compounds (xenobiotics), have great potential to modulate the activity of cytochrome P450s (CYPs), xenobiotic-metabolizing enzymes involved in the activation and detoxification of food and environmental carcinogens. Thus, the aim of this study was to investigate the effects of model glycosylated and deglycosylated flavonoids on CYPs in rat liver and small intestine, as the two main organs responsible for xenobiotic metabolism, after p.o. administration by gastric gavages. The effects of two glycosylated flavonoids (isoquercitrin, rutin) and their aglycone (quercetin) on CYPs were determined using Western blotting technique and specific activity assays with alkyl-resorufin derivatives. In liver microsomes, a considerable increase of all the measured marker activities (EROD, MROD, PROD) was observed only after isoquercitrin treatment. Obtained data demonstrate the different effects of flavonoid glycosides and aglycone on CYP expression in rat liver and small intestine Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2010
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