Počet záznamů: 1  

The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine

  1. 1.
    SYSNO ASEP0334401
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JOstatní články
    NázevThe effects of selected flavonoids on cytochromes P450 in rat liver and small intestine
    Tvůrce(i) Křížková, J. (CZ)
    Burdová, K. (CZ)
    Stiborová, M. (CZ)
    Křen, Vladimír (MBU-M) RID, ORCID
    Hodek, P. (CZ)
    Zdroj.dok.Interdisciplinary Toxicology - ISSN 1337-6853
    Roč. 2, č. 3 (2009), s. 201-204
    Poč.str.4 s.
    Jazyk dok.eng - angličtina
    Země vyd.SK - Slovensko
    Klíč. slovaflavonoids ; cytochrome p450 ; small intestine
    Vědní obor RIVEE - Mikrobiologie, virologie
    CEPGD305/09/H008 GA ČR - Grantová agentura ČR
    CEZAV0Z50200510 - MBU-M (2005-2011)
    DOI10.2478/v10102-009-0018-y
    AnotaceFlavonoids, as foreign compounds (xenobiotics), have great potential to modulate the activity of cytochrome P450s (CYPs), xenobiotic-metabolizing enzymes involved in the activation and detoxification of food and environmental carcinogens. Thus, the aim of this study was to investigate the effects of model glycosylated and deglycosylated flavonoids on CYPs in rat liver and small intestine, as the two main organs responsible for xenobiotic metabolism, after p.o. administration by gastric gavages. The effects of two glycosylated flavonoids (isoquercitrin, rutin) and their aglycone (quercetin) on CYPs were determined using Western blotting technique and specific activity assays with alkyl-resorufin derivatives. In liver microsomes, a considerable increase of all the measured marker activities (EROD, MROD, PROD) was observed only after isoquercitrin treatment. Obtained data demonstrate the different effects of flavonoid glycosides and aglycone on CYP expression in rat liver and small intestine
    PracovištěMikrobiologický ústav
    KontaktEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Rok sběru2010
Počet záznamů: 1  

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