Počet záznamů: 1
Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression
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SYSNO ASEP 0334133 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Confocal microscopy reveals Myzitiras and Vthela morphotypes as new signatures of malignancy progression Tvůrce(i) Veselý, Pavel (UMG-J)
Rösel, D. (CZ)
Paňková, D. (CZ)
Tolde, O. (CZ)
Blase, C. (DE)
Matoušková, E. (CZ)
Folk, P. (CZ)
Brábek, J. (CZ)
Bereiter-Hahn, J. (DE)Celkový počet autorů 9 Zdroj.dok. Scanning - ISSN 0161-0457
Roč. 31, č. 3 (2009), s. 102-106Poč.str. 5 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova dynamic morphology ; cinemicroscopy ; breast carcinoma ; malignancy progression Vědní obor RIV EB - Genetika a molekulární biologie CEP LC06061 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000268426100002 DOI 10.1002/sca.20146 Anotace G3S1 cells are a new line derived from EM-G3 breast cancer cells by chronic nutritional stress and treatments with 12-O-tetradecanoylphorbol-13-acetate. These cells are capable of growing in standard medium. G3S1 cells exhibited elevated invasiveness in Matrigel invasion chambers as compared with parental EM-G3 cells. Elevated invasiveness of G3S1 cells was accompanied by higher incidence of myzitiras morphotype (sucker-like) and newly observed vthela morphotype (leech-like) both inducible in Hanks Balanced Salt Solution test. Time-lapse phase contrast microscopy showed a capacity of G3S1 cells to form lobopodial protrusions already 20 min after seeding on gelatin. These protrusions could make contact with the dish and possibly produce the vthela shape. The possible relationship of mysitiras and vthela morphotypes to an increase in malignant potential marked by enhanced invasiveness was thus indicated. Copyright 2009 Wiley Periodicals, Inc. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
Počet záznamů: 1