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CpG methylation controls reactivation of HIV from latency
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SYSNO ASEP 0333948 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název CpG methylation controls reactivation of HIV from latency Tvůrce(i) Blažková, Jana (UMG-J)
Trejbalová, Kateřina (UMG-J) RID
Gondois-Rey, F. (FR)
Halfon, P. (FR)
Philibert, P. (FR)
Guiguen, A. (BE)
Verdin, E. (US)
Olive, D. (FR)
Van Lint, C. (BE)
Hejnar, Jiří (UMG-J) RID
Hirsch, I. (FR)Zdroj.dok. PLoS Pathogens. - : Public Library of Science - ISSN 1553-7366
Roč. 5, č. 8 (2009), e1000554-e1000554Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova HIV-1 ; proviral latency ; CpG methylation ; histone modifications ; HAART ; epigenetics Vědní obor RIV EB - Genetika a molekulární biologie CEP GA204/05/0939 GA ČR - Grantová agentura ČR GP204/08/P616 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000270804500010 DOI 10.1371/journal.ppat.1000554 Anotace HIV-1 latency is the main obstacle to the eradication of the virus from infected patients. CpG methylation is known to contribute to transcriptional silencing in general, its role in HIV-1 latency, however, has not been clearly demonstrated and has never been studied in HIV-1-infected patients. We found in an in vitro model and in HIV-1-infected patients that CpG methylation of the HIV-1 promoter is important for the maintenance but not for the establishment of HIV-1 latency. That tight control of HIV-1 latency by CpG methylation could be a key barrier to purging the reservoir of latently infected cells in infected individuals. Our study shows that addition of some histone deacetylase and methyltransferase inhibitors (namely SAHA) reactivate latent HIV and could represent an important part of HAART protocols in the future. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
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