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A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007
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SYSNO ASEP 0333601 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007 Tvůrce(i) Linka, M. (CZ)
Brůčková, M. (CZ)
Malý, M. (CZ)
Vandasová, J. (CZ)
Stanková, M. (CZ)
Reiniš, Milan (UMG-J) RIDZdroj.dok. Central European Journal of Public Health. - : Státní zdravotní ústav - ISSN 1210-7778
Roč. 16, č. 4 (2009), s. 175-177Poč.str. 3 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova HIV-1 subtyping ; non-B subtypes ; molecular epidemiology Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520514 - UMG-J (2005-2011) Anotace The global HIV/AIDS epidemic consists of a number of regional epidemics caused by different HIV-1 subtypes prevailing in different regions. We have studied changes in genetic diversity of HIV-1 strains isolated in the Czech Republic (CR) over a more than twenty-year period (1986–2007). HIV-1 strains isolated in CR from 1986 to 2007 were subtyped by pol gene sequencing followed by phylogenetic analysis. A wide range of HIV-1 subtypes were found, with subtype B, into which 76.6 % of 534 HIV-1 isolates were classified, being predominant during the whole study period. An increasing number of non-B subtypes A1, C, D, F1, G and some recombinant forms (CRF 01_AE, CRF 02_AG and CRF 06_cpx) were identified after 1990. The absolute predominance of subtype B among HIV-1 strains in CR ended in 1991 when different non-B subtypes had been introduced into the country. The East-West migration is responsible for the introduction of HIV-1 subtypes prevalent in Eastern European and some Asian countries. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
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