Počet záznamů: 1
Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice
- 1.
SYSNO ASEP 0333492 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Anorexigenic effect of cholecystokinin is lost but that of CART (cocaine and amphetamine regulated transcript) peptide is preserved in monosodium glutamate obese mice Tvůrce(i) Železná, Blanka (UOCHB-X) RID, ORCID
Maixnerová, Jana (UOCHB-X)
Matyšková, Resha (UOCHB-X)
Haugvicová, Renata (MBU-M)
Blokešová, Darja (UOCHB-X)
Maletínská, Lenka (UOCHB-X) RID, ORCIDCelkový počet autorů 6 Zdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 58, č. 5 (2009), s. 717-723Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova monosodium glutamate (MSG) obesity ; neuropeptide Y (NPY) ; cholecystokinin Vědní obor RIV CC - Organická chemie CEP GA303/05/0614 GA ČR - Grantová agentura ČR CEZ AV0Z40550506 - UOCHB-X (2005-2011) AV0Z5020903 - MBU-M UT WOS 000272080200013 Anotace Monosodium glutamate (MSG) treatment of neonatal mice results in a selective damage to the arcuate nucleus (ARC) and development of obesity. The MSG obese mice do not respond to fasting by an increased food intake which makes difficult to measure the effect of peptides attenuating food intake such as cholecystokinin (CCK) or cocaine- and amphetamine-regulated transcript (CART) peptide. However, orexigenic effect of NPY is preserved in the fed MSG obese rodents. In this study with fed lean and MSG obese C57BL/6 male mice, short-term food intake was measured after simultaneous central administration of orexigenic NPY with either CART peptide or peripherally administered CCK. Anorexigenic action of exogenous CART peptide was preserved in MSG obese mice. On the other hand, satiety effect of exogenous CCK was completely lost in MSG obese mice probably because of ineffective leptin signaling in ARC. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2010
Počet záznamů: 1