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Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS
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SYSNO ASEP 0332235 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS Tvůrce(i) Herynek, V. (CZ)
Růžičková, Kateřina (UEM-P)
Jendelová, Pavla (UEM-P) RID, ORCID
Syková, Eva (UEM-P) RID
Hájek, M. (CZ)Zdroj.dok. Magnetic Resonance Materials in Physics, Biology and Medicine. - : Springer - ISSN 0968-5243
Roč. 22, č. 4 (2009), s. 211-220Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova mesenchymal stem cell transplantation ; magnetic resonance spectroscopy ; rats Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP KAN201110651 GA AV ČR - Akademie věd LC554 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA309/06/1594 GA ČR - Grantová agentura ČR CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000268903800002 DOI 10.1007/s10334-009-0166-2 Anotace The article describes the metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation. 1H MRS revealed a gradual recovery of the damaged tissue; however, we found no significant differences in metabolite concentrations in the lesioned hemisphere between treated and untreated animals. Higher concentrations of glutamate and N-acetyl aspartate were found in the contralateral hemisphere in cell-treated animals compared to untreated ones. Lesioned animals showed neurogenesis in the contralateral hemisphere; the number of newly generated cells in stem cell-treated animals was 50% higher than that observed in untreated animals. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2010
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