Počet záznamů: 1
Identification of the first toll-like receptor gene in passerine birds: TLR4 orthologue in zebra finch (Taeniopygia guttata)
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SYSNO ASEP 0325112 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Identification of the first toll-like receptor gene in passerine birds: TLR4 orthologue in zebra finch (Taeniopygia guttata) Překlad názvu Identifikace prvního Toll-like receptoru u pěvce: TLR4 ortolog u zebřičky (Taeniopygia guttata) Tvůrce(i) Vinkler, Michal (UBO-W) RID, ORCID
Bryjová, Anna (UBO-W) SAI, ORCID
Albrecht, Tomáš (UBO-W) RID, SAI, ORCID
Bryja, Josef (UBO-W) RID, SAI, ORCIDZdroj.dok. Tissue Antigens - ISSN 0001-2815
Roč. 74, č. 1 (2009), s. 32-41Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. DK - Dánsko Klíč. slova avian immunogenetics ; comparative immunology ; evolutionary immunology Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA600930608 GA AV ČR - Akademie věd LC06073 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z60930519 - UBO-W (2005-2011) UT WOS 000266876500005 EID SCOPUS 66949152875 DOI 10.1111/j.1399-0039.2009.01273.x Anotace Toll-like receptors (TLRs) are the basic components of the vertebrate pathogen recognition system. Despite uniform general structure, remarkable variability in domain composition can be found in individual TLRs among species. Knowledge of interspecific differences is of particular importance to our understanding of selective pressures on TLRs. Currently, most TLRs are characterized only in a limited number of model species, including domestic chicken as a universal avian model. Here, we describe structure and expression pattern of TLR4 in zebra finch, a widely used passerine model species. The tgTlr4 gene consists of three exons (204, 167 and 3033–3043 bp) that are transcribed into messenger RNA. Predicted protein is composed of 842 amino acids. The gene is highly expressed in the bone marrow and in the spleen. For the first time in birds, expression of tgTLR4 in peritoneal macrophages was found to be enhanced by the Escherichia coli lipopolysaccharide treatment. Pracoviště Ústav biologie obratlovců Kontakt Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Rok sběru 2010
Počet záznamů: 1