Počet záznamů: 1

Identification of the first toll-like receptor gene in passerine birds: TLR4 orthologue in zebra finch (Taeniopygia guttata)

SYSNO ASEP	0325112
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Identification of the first toll-like receptor gene in passerine birds: TLR4 orthologue in zebra finch (Taeniopygia guttata)
Překlad názvu	Identifikace prvního Toll-like receptoru u pěvce: TLR4 ortolog u zebřičky (Taeniopygia guttata)
Tvůrce(i)	Vinkler, Michal (UBO-W)_{RID, ORCID} Bryjová, Anna (UBO-W)_{SAI, ORCID} Albrecht, Tomáš (UBO-W)_{RID, SAI, ORCID} Bryja, Josef (UBO-W)_{RID, SAI, ORCID}
Zdroj.dok.	Tissue Antigens - ISSN 0001-2815 Roč. 74, č. 1 (2009), s. 32-41
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	DK - Dánsko
Klíč. slova	avian immunogenetics ; comparative immunology ; evolutionary immunology
Vědní obor RIV	EB - Genetika a molekulární biologie
CEP	IAA600930608 GA AV ČR - Akademie věd
	LC06073 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy
CEZ	AV0Z60930519 - UBO-W (2005-2011)
UT WOS	000266876500005
EID SCOPUS	66949152875
DOI	10.1111/j.1399-0039.2009.01273.x
Anotace	Toll-like receptors (TLRs) are the basic components of the vertebrate pathogen recognition system. Despite uniform general structure, remarkable variability in domain composition can be found in individual TLRs among species. Knowledge of interspecific differences is of particular importance to our understanding of selective pressures on TLRs. Currently, most TLRs are characterized only in a limited number of model species, including domestic chicken as a universal avian model. Here, we describe structure and expression pattern of TLR4 in zebra finch, a widely used passerine model species. The tgTlr4 gene consists of three exons (204, 167 and 3033–3043 bp) that are transcribed into messenger RNA. Predicted protein is composed of 842 amino acids. The gene is highly expressed in the bone marrow and in the spleen. For the first time in birds, expression of tgTLR4 in peritoneal macrophages was found to be enhanced by the Escherichia coli lipopolysaccharide treatment.
Pracoviště	Ústav biologie obratlovců
Kontakt	Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
Rok sběru	2010

Počet záznamů: 1