Počet záznamů: 1  

Future use of mitocans against tumour-initiating cells?

  1. 1.
    SYSNO ASEP0325050
    Druh ASEPJ - Článek v odborném periodiku
    Zařazení RIVJ - Článek v odborném periodiku
    Poddruh JČlánek ve WOS
    NázevFuture use of mitocans against tumour-initiating cells?
    Tvůrce(i) Morrison, B.J. (AU)
    Anděra, Ladislav (UMG-J) RID
    Reynolds, B.A. (AU)
    Ralph, S.J. (AU)
    Neužil, Jiří (BTO-N) RID
    Celkový počet autorů5
    Zdroj.dok.Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125
    Roč. 53, č. 1 (2009), s. 147-153
    Poč.str.7 s.
    Jazyk dok.eng - angličtina
    Země vyd.DE - Německo
    Klíč. slovamitocans ; tumour-initiating cells ; metastasis
    Vědní obor RIVEB - Genetika a molekulární biologie
    CEZAV0Z50520514 - UMG-J (2005-2011)
    AV0Z50520701 - BTO-N (2007-2013)
    UT WOS000262869400013
    DOI10.1002/mnfr.200800254
    AnotaceTumour heterogeneity has several important consequences including making their classification by morphological and genetic analysis more difficult because of the diversity of cells, failing to eliminate one of the cell subtypes and differing abilities of the cell subtypes for dissemination and metastasis. Recently, a rare subpopulation of cells within tumours has been described with the ability to initiate and sustain tumour growth, to resist traditional therapies and to allow for secondary tumour dissemination. These cells are termed tumour-initiating cells (TICs). Understanding tumour heterogeneity will be critical for advancing treatments for cancer that target TIC subpopulations of cells in a tumour able to resist traditional treatments and eliminate them before metastatic disease occurs. Therefore, knowledge of the molecular mechanism(s) of resistance of TICs to treatment and overcoming it will be essential in order to develop effective drug strategies for cancer therapy.
    PracovištěÚstav molekulární genetiky
    KontaktNikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
    Rok sběru2010
Počet záznamů: 1  

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