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Mitochondria as targets for cancer therapy
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SYSNO ASEP 0325040 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mitochondria as targets for cancer therapy Překlad názvu Mitochondrie jako zásahové místo terapie rakoviny Tvůrce(i) Ralph, S.J. (AU)
Neužil, Jiří (BTO-N) RIDZdroj.dok. Molecular Nutrition & Food Research. - : Wiley - ISSN 1613-4125
Roč. 53, č. 1 (2009), s. 9-28Poč.str. 19 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova Apoptosis ; mitocans ; cancer Vědní obor RIV EB - Genetika a molekulární biologie CEZ AV0Z50520701 - BTO-N (2007-2013) UT WOS 000262869400003 DOI 10.1002/mnfr.200800044 Anotace Mitochondria have recently emerged as intriguing targets for anticancer drugs. A variety of compounds, termed mitocans, have been identified that act via mitochondria. They destabilise mitochondria and cause apoptosis, which is, in some cases, selective for cancer cells. Mitochondria are the powerhouse of the cell, as well as the source of mediators of apoptosis. Individual types of cancers are complex and can differ considerably in their array of DNA mutations, harbouring different sets of genetic causes. This indicates that it will be very unlikely to cure cancer by drugs targeting only a few gene products or single pathways that are essential for tumour survival. What is needed then is an invariant target, common to all cells, but which is predominantly only affected by drugs when delivered inside the cancer cells. Such targets appear to be mitochondria, with very rare mutations, and mitocans can be expected to be efficient drugs for different types of the neoplastic disease Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2009
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