Počet záznamů: 1
Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic
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SYSNO ASEP 0314441 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in Czech Republic Tvůrce(i) Poláková, Veronika (UEM-P) RID
Pardini, Barbara (UEM-P)
Naccarati, Alessio (UEM-P)
Landi, S. (IT)
Slyšková, Jana (UEM-P) RID
Novotný, J. (CZ)
Vodičková, Ludmila (UEM-P) RID
Bermejo, J.L. (DE)
Hánová, Monika (UEM-P)
Šmerhovský, Z. (CZ)
Tulupová, Elena (UEM-P)
Kumar, R. (DE)
Hemminki, K. (DE)
Vodička, Pavel (UEM-P) RIDZdroj.dok. Human Mutation. - : Wiley - ISSN 1059-7794
Roč. 30, č. 4 (2009), s. 661-668Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova TP53 ; CDKN1A ; genetic polymorphisms Vědní obor RIV EB - Genetika a molekulární biologie CEP GA310/07/1430 GA ČR - Grantová agentura ČR CEZ AV0Z50390703 - UEM-P (2007-2013) AV0Z50390512 - UEM-P (2005-2011) UT WOS 000265006400021 DOI 10.1002/humu.20931 Anotace To assess the role of genetic variants on the disease, we genotyped polymorphisms in the TP53 (rs17878362:A1>A2, rs1042522:G>C, rs12947788:C>T, and rs17884306:G>A), CDKN1A (rs1801270:C>A and rs1059234:C>T), and CDKN2A (rs3731249:G>A, rs11515:C>G, and rs3088440:C>T) genes in 614 hospital-based colorectal cancer cases and 614 matched controls from the country. The two most common haplotypes, A1GCG and A2CCG were present in 81% of the cases compared to 71% of the controls. In comparison to the most common haplotype (A1GCG), the haplotype A2CCG was associated with an increased risk (odds ratio OR 1.40, 95% confidence interval CI 1.07-1.82), while the four other haplotypes A1CCG (OR 0.60 95% CI 0.45-0.79), A2GCG (OR 0.53 95% CI 0.35-0.81), A1GTG (OR 0.31 95% CI 0.15-0.64), and A1GCA (OR 0.19 95% CI 0.07-0.51) were associated with a decreased risk. No association with the disease was observed with haplotypes of the CDKN1A and CDKN2A polymorphisms. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2010
Počet záznamů: 1