Počet záznamů: 1
Synthesis of Tumor Necrosis Factor Alpha Induced Protein 6 in Porcine Preovulatory Follicles; A Study with A38 Antibody
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SYSNO ASEP 0306895 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Synthesis of Tumor Necrosis Factor Alpha Induced Protein 6 in Porcine Preovulatory Follicles; A Study with A38 Antibody Překlad názvu Syntéza TNFAIP6 v předovulačních folikulech prasat. Sledování vlivu protilátky A38 Tvůrce(i) Nagyová, Eva (UZFG-Y) RID, ORCID
Camaioni, A. (IT)
Procházka, Radek (UZFG-Y) RID, ORCID
Day, A. J. (GB)
Salustri, A. (IT)Zdroj.dok. Biology of Reproduction. - : Oxford University Press - ISSN 0006-3363
Roč. 78, - (2008), s. 903-909Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cumulus cells ; extracellular matrix ; hyaluronan Vědní obor RIV EB - Genetika a molekulární biologie CEP GA305/05/0960 GA ČR - Grantová agentura ČR CEZ AV0Z50450515 - UZFG-Y (2005-2011) Anotace Our results, together with the high sequence similarity found among human, rabbit, mouse, rat, bovine and equine TNFAIP6 and the expression of this protein and/or the respective gene in preovulatory follicles of all the examined species, strongly support the concept that TNFAIP6-mediated HC covalent transfer onto hyaluronic acid (HA) synthesized by cumulus cells is a mechanism common to mammalian OCCs. However, in contrast to the situation observed in the mouse, anti-TNFAIP6 A38 antibody did not prevent cumulus expansion nor HA accumulation in the matrix of pig OCCs stimulated with FSH. It suggests that porcine OCCs have evolved supplemental mechanisms for holding HA in the matrix. Thus, it is reasonable to hypothesize that different relative levels of HA, TNFAIP6, versican as well as other matrix components are synthesized by cumulus cells of different species, with the aim to create for each species the matrix that is the most suitable for ovulation and oocyte fertilization. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2008
Počet záznamů: 1