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Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction
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SYSNO ASEP 0142279 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Temperature effect on carbachol-induced depression of spontaneous quantal transmitter release in frog neuromuscular junction Tvůrce(i) Strunsky, E. G. (RU)
Borisover, M. D. (IL)
Nikolsky, E. E. (RU)
Vyskočil, František (FGU-C) RIDZdroj.dok. Neurochemical Research. - : Springer - ISSN 0364-3190
Roč. 26, 8-9 (2001), s. 891-897Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova carbachol ; temperature ; acetylcholine release Vědní obor RIV ED - Fyziologie CEP IAA7011902 GA AV ČR - Akademie věd OK 267 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z5011922 - FGU-C Anotace The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60 and the temperature dependence was negligible. However, an inverse temperature dependence was found when low concentrations 3 x 10(-7) and 6 x 10(-7) M were applied. The depression of f was 40-50 in 5-10 degrees C but only 10-20 of the control in the 25 and 30 degrees C. During application of CCh, the new steady of f was reached at temperatures between 5 and 30 degrees C within 17-20 min (Q10 = 1.07). Much greater temperature dependence of recovery was observed during washing out CCh (Q10 = 1.6). The temperature-independence of the steady state effects of CCh, good agreement with Langmuir adsorption-desorption theory and non-steady kinetics indicate that physical rather than receptor-mediated events are responsible for the depression of f. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2002
Počet záznamů: 1