Počet záznamů: 1
The role of desensititation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria
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SYSNO ASEP 0142139 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název The role of desensititation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria Tvůrce(i) Giniatullin, R. A. (CZ)
Talantova, M. V. (CZ)
Vyskočil, František (FGU-C) RIDZdroj.dok. Neuroscience Research. - : Elsevier - ISSN 0168-0102
Roč. 39, č. 3 (2001), s. 287-292Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. IE - Irsko Klíč. slova frog ; desensitisation ; miniature endplate potential Vědní obor RIV ED - Fyziologie CEP IAA7011902 GA AV ČR - Akademie věd VS97099 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy OK 267 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z5011922 - FGU-C Anotace A new comparative characteristic of endplate microphysiology has been introduced. It is the feasibility of receptors to become desensitised as demonstrated on two frog species, Rana temporaria and Rana ridibunda: the decay times (tau(MEPC)) of single quantum miniature endplate currents (MEPCs) in the sartorius muscles of both species were about 1 ms and were not affected by the desensitisation-promoting agent proadifen when AChE was active. However, when the desensitisation was induced by anticholinesterase neostigmine and promoted by proadifen, the prolongation of tau(MEPC) from 1 ms was almost twice as great in Rana temporaria (tau(MEPC) = 4.4 ms) than in Rana ridibunda (tau(MEPC) = 3.1). This indicates that desensitisation reduces the number of available receptors and lowers the number of available ACh molecules for repetitive binding by trapping them by desensitised, high-affinity receptors significantly more in Rana ridibunda than in Rana temporaria. The application of proadifen, a promoter of desensitisation, decreased the prolongation of MEPCs in both species, but this shortening was more rapid in Rana ridibunda than in Rana temporaria. It is concluded that the desensitisation-induced reduction in the density, and the number of postsynaptic receptors is significantly higher at Rana ridibunda than in Rana temporaria endplates. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2002
Počet záznamů: 1