Počet záznamů: 1
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines
- 1.
SYSNO ASEP 0126967 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine or 4-picoline ligand in cell-free media. Relations to their activity in cancer cell lines Tvůrce(i) Kašpárková, Jana (BFU-R) RID, ORCID
Marini, Victoria (BFU-R)
Najajreh, Y. (IL)
Gibson, D. (IL)
Brabec, Viktor (BFU-R) RID, ORCIDZdroj.dok. Biochemistry. - : American Chemical Society - ISSN 0006-2960
Roč. 42, č. 20 (2003), s. 6321-6332Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cross links ; DNA ; nonclassical platinum complexes Vědní obor RIV BO - Biofyzika CEP IAA5004101 GA AV ČR - Akademie věd KJB5004301 GA AV ČR - Akademie věd GA305/01/0418 GA ČR - Grantová agentura ČR CEZ AV0Z5004920 - BFU-R Anotace The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl2(NH3)(Am)], where Am = NH3, nonplanar heterocycle piperidine, piperazine, or aromatic planar heterocycle 4-picoline, was investigated in cell-free media. These modifications have been compared with the activity of these new compounds in several tumor cell lines. The results show that the replacement of the NH3 group in cisplatin by the heterocyclic ligands does not considerably affect the DNA binding mode of this drug. In contrast to the analogues of cisplatin, the replacement of one ammine group by the heterocyclic ligand in its clinically ineffective trans isomer (transplatin) results in a radical enhancement of its activity in tumor cell lines. This replacement also markedly alters the DNA binding mode of transplatin. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2004
Počet záznamů: 1