Depletion of Treg cells augments the therapeutic effect of cancer vaccines
1.
SYSNO ASEP
0047250
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Depletion of Treg cells augments the therapeutic effect of cancer vaccines
Překlad názvu
Deplece T regulačních buněk zvyšuje terapeutický účinek nádorových vakcín
Tvůrce(i)
Bubeník, Jan (UMG-J)
Zdroj.dok.
Folia Biologica. - : Univerzita Karlova v Praze
- ISSN 0015-5500
Roč. 52, č. 6 (2006), s. 202-204
Poč.str.
3 s.
Jazyk dok.
eng - angličtina
Země vyd.
CZ - Česká republika
Klíč. slova
Treg cells ; cancer vaccines
Vědní obor RIV
EB - Genetika a molekulární biologie
CEZ
AV0Z50520514 - UMG-J (2005-2011)
Anotace
CD4+ T suppressor cells constitutively expressing interleukin-2 receptor chain (CD25) can maintain immunologic self-tolerance and have been designated regulatory T cells (Tregs). In experimental tumour model systems depletion of Treg cells has been shown to augment the therapeutic effect of different cancer vaccines. A variety of strategies for the induction and enhancement of specific anti-tumour immune responses based on Treg depletion are being tested in pre-clinical and clinical settings. Whereas in most experimental tumour models these strategies provided satisfactory results, in cancer patients their success was rather episodic, and many basic as well as technical problems have still to be solved before the therapeutic protocols for the depletion of specific adaptive Tregs in cancer patients can be proposed. Nevertheless, the depletion of Tregs belongs at present to the highlights of prospective cancer immunotherapy, particularly as a potent adjuvant to cancer vaccines.
