Počet záznamů: 1
Auxin inhibits endocytosis and promotes its own efflux from cells
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SYSNO ASEP 0023924 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Auxin inhibits endocytosis and promotes its own efflux from cells Překlad názvu Auxin inhibuje endocytosu a podporuje svůj export z buněk Tvůrce(i) Paciorek, T. (DE)
Zažímalová, Eva (UEB-Q) RID, ORCID
Ruthardt, N. (DE)
Petrášek, Jan (UEB-Q) RID, ORCID
Stierhof, Y. D. (DE)
Kleine-Vehn, J. (DE)
Morris, David (UEB-Q)
Emans, N. (DE)
Jürgens, G. (DE)
Geldner, N. (DE)
Friml, J. (CZ)Zdroj.dok. Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 435, č. 7046 (2005), s. 1251-1256Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Phytohormones ; polar auxin transport ; plasma membrane Vědní obor RIV EB - Genetika a molekulární biologie CEP IAA6038303 GA AV ČR - Akademie věd CEZ AV0Z50380511 - UEB-Q (2005-2011) Anotace One of the mechanisms by which signalling molecules regulate cellular behaviour is modulating subcellular protein translocation. This mode of regulation is often based on specialized vesicle trafficking, termed constitutive cycling, which consists of repeated internalization and recycling of proteins to and from the plasma membrane(1). No such mechanism of hormone action has been shown in plants although several proteins, including the PIN auxin efflux facilitators, exhibit constitutive cycling(2,3). Here we show that a major regulator of plant development, auxin, inhibits endocytosis. This effect is specific to biologically active auxins and requires activity of the Calossin-like protein BIG. By inhibiting the internalization step of PIN constitutive cycling, auxin increases levels of PINs at the plasma membrane. Concomitantly, auxin promotes its own efflux from cells by a vesicle-trafficking-dependent mechanism. Furthermore, asymmetric auxin translocation during gravitropism is correlated with decreased PIN internalization. Our data imply a previously undescribed mode of plant hormone action: by modulating PIN protein trafficking, auxin regulates PIN abundance and activity at the cell surface, providing a mechanism for the feedback regulation of auxin transport. Pracoviště Ústav experimentální botaniky Kontakt David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Rok sběru 2006
Počet záznamů: 1