Alpha-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1
1.
SYSNO ASEP
0001288
Druh ASEP
J - Článek v odborném periodiku
Zařazení RIV
J - Článek v odborném periodiku
Poddruh J
Ostatní články
Název
Alpha-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1
Překlad názvu
Alfa-tokoferyl sukcinát vyvolává v buňkách osteosarkomu cytostázu a apoptózu: úloha E2F1
Tvůrce(i)
Alleva, R. (IT) Benassi, M.S. (IT) Tomasetti, M. (IT) Gellert, N. (AU) Ponticelli, F. (IT) Borghi, B. (IT) Picci, P. (IT) Neužil, Jiří (UMG-J)
Zdroj.dok.
Biochemical and Biophysical Research Communications. - : Elsevier
- ISSN 0006-291X
Roč. 331, č. 4 (2005), s. 1515-1521
Poč.str.
7 s.
Jazyk dok.
eng - angličtina
Země vyd.
US - Spojené státy americké
Klíč. slova
osteosarcoma ; alpha-tocopheryl succinate ; E2F1
Vědní obor RIV
EB - Genetika a molekulární biologie
CEZ
AV0Z50520514 - UMG-J (2005-2011)
AV0Z5052915 - UMG-J
Anotace
Alpha-tocopheryl succinate (alpha-TOS), a redox-inactive analog of vitamin E, induces cell cycle arrest, differentiation, and triggers apoptosis. We examined the ability of alpha-TOS to induce cytostasis and/or apoptosis in two human osteosarcoma cell lines, which carry wild-type pRb but differ in the p53 status. In the wt-p53 cells, alpha-TOS induced apoptosis, which was associated with p53 activation and enhanced E2F1 expression. Mutant p53 cells failed to undergo apoptosis when challenged with alpha-TOS. The cell growth arrest after alpha-TOS treatment was associated with a reduced expression of E2F1. Knocking down E2F1 rendered the alpha-TOS-sensitive cells rather resistant to the apoptotic stimulus inducing a marked and prolonged cell growth arrest. We conclude that alpha-TOS induces cell growth arrest or apoptosis involving E2F1.
