Structural insights into the functional roles of 14-3-3 proteins

0562211 - FGÚ 2023 RIV CH eng J - Článek v odborném periodiku
Obšilová, Veronika - Obšil, T.
Structural insights into the functional roles of 14-3-3 proteins.
Frontiers in molecular biosciences. Roč. 9, Sep 16 (2022), č. článku 1016071. E-ISSN 2296-889X
Grant CEP: GA ČR(CZ) GA21-02080S; GA ČR(CZ) GA19-00121S
Institucionální podpora: RVO:67985823
Klíčová slova: 14-3-3 proteins * protein-protein interactions * phosphorylation * molecular mechanism * scaffolding * adaptor protein
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 5, rok: 2022
Způsob publikování: Open access
https://doi.org/10.3389/fmolb.2022.1016071

Signal transduction cascades efficiently transmit chemical and/or physical signals from the extracellular environment to intracellular compartments, thereby eliciting an appropriate cellular response. Most often, these signaling processes are mediated by specific protein-protein interactions involving hundreds of different receptors, enzymes, transcription factors, and signaling, adaptor and scaffolding proteins. Among them, 14-3-3 proteins are a family of highly conserved scaffolding molecules expressed in all eukaryotes, where they modulate the function of other proteins, primarily in a phosphorylation-dependent manner. Through these binding interactions, 14-3-3 proteins participate in key cellular processes, such as cell-cycle control, apoptosis, signal transduction, energy metabolism, and protein trafficking. To date, several hundreds of 14-3-3 binding partners have been identified, including protein kinases, phosphatases, receptors and transcription factors, which have been implicated in the onset of various diseases. As such, 14-3-3 proteins are promising targets for pharmaceutical interventions. However, despite intensive research into their protein-protein interactions, our understanding of the molecular mechanisms whereby 14-3-3 proteins regulate the functions of their binding partners remains insufficient. This review article provides an overview of the current state of the art of the molecular mechanisms whereby 14-3-3 proteins regulate their binding partners, focusing on recent structural studies of 14-3-3 protein complexes.
Trvalý link: https://hdl.handle.net/11104/0334618