Počet záznamů: 1
Fluorine-containing block and gradient copoly(2-oxazoline)s based on 2-(3,3,3-trifluoropropyl)-2-oxazoline: a quest for the optimal self-assembled structure for 19F imaging
- 1.0543732 - ÚMCH 2022 RIV US eng J - Článek v odborném periodiku
Kaberov, Leonid I. - Kaberova, Zhansaya - Murmiliuk, A. - Trousil, Jiří - Sedláček, O. - Konefal, Rafal - Zhigunov, Alexander - Pavlova, Ewa - Vít, M. - Jirák, D. - Hoogenboom, R. - Filippov, S. K.
Fluorine-containing block and gradient copoly(2-oxazoline)s based on 2-(3,3,3-trifluoropropyl)-2-oxazoline: a quest for the optimal self-assembled structure for 19F imaging.
Biomacromolecules. Roč. 22, č. 7 (2021), s. 2963-2975. ISSN 1525-7797. E-ISSN 1526-4602
Grant CEP: GA ČR(CZ) GA17-00973S; GA MŠk(CZ) LTC19032; GA MŠk(CZ) LO1507; GA ČR(CZ) GA19-01602S
Grant ostatní: AV ČR(CZ) FWO-17-05; AV ČR(CZ) FWO-19-03
Program: Bilaterální spolupráce; Bilaterální spolupráce
Institucionální podpora: RVO:61389013
Klíčová slova: poly(2-oxazolines) * self-assembly * fluorine
Obor OECD: Polymer science
Impakt faktor: 6.978, rok: 2021
Způsob publikování: Omezený přístup
The use of fluorinated contrast agents in magnetic resonance imaging (MRI) facilitates improved image quality due to the negligible amount of endogenous fluorine atoms in the body. In this work, we present a comprehensive study of the influence of the amphiphilic polymer structure and composition on its applicability as contrast agents in 19F MRI. Three series of novel fluorine-containing poly(2-oxazoline) copolymers and terpolymers, hydrophilic–fluorophilic, hydrophilic–lipophilic–fluorophilic, and hydrophilic–thermoresponsive–fluorophilic, with block and gradient distributions of the fluorinated units, were synthesized. It was discovered that the CF3 in the 2-(3,3,3-trifluoropropyl)-2-oxazoline (CF3EtOx) group activated the cationic chain end, leading to faster copolymerization kinetics, whereby spontaneous monomer gradients were formed with accelerated incorporation of 2-methyl-2-oxazoline or 2-n-propyl-2-oxazoline with a gradual change to the less-nucleophilic CF3EtOx monomer. The obtained amphiphilic copolymers and terpolymers form spherical or wormlike micelles in water, which was confirmed using transmission electron microscopy (TEM), while small-angle X-ray scattering (SAXS) revealed the core–shell or core–double-shell morphologies of these nanoparticles. The core and shell sizes obey the scaling laws for starlike micelles predicted by the scaling theory. Biocompatibility studies confirm that all copolymers obtained are noncytotoxic and, at the same time, exhibit high sensitivity during in vitro 19F MRI studies. The gradient copolymers provide the best 19F MRI signal-to-noise ratio in comparison with the analogue block copolymer structures, making them most promising as 19F MRI contrast agents.
Trvalý link: http://hdl.handle.net/11104/0321934
Počet záznamů: 1