Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia

0543462 - ÚI 2022 RIV IE eng J - Článek v odborném periodiku
Janča, R. - Jahodová, A. - Hlinka, Jaroslav - Ježdík, P. - Svobodová, L. - Kudr, M. - Kalina, A. - Marusič, P. - Kršek, P. - Jiruška, Přemysl
Ictal Gamma-Band Interactions Localize Ictogenic Nodes of the Epileptic Network in Focal Cortical Dysplasia.
Clinical Neurophysiology. Roč. 132, č. 8 (2021), s. 1927-1936. ISSN 1388-2457. E-ISSN 1872-8952
Grant CEP: GA MZd(CZ) NV17-28427A
Grant ostatní: GA ČR(CZ) GA20-21339S
Institucionální podpora: RVO:67985807 ; RVO:67985823
Klíčová slova: Epilepsy * Effective connectivity * Intracranial EEG * Networks * Seizure onset zone * Outcome
Obor OECD: Neurosciences (including psychophysiology; Neurosciences (including psychophysiology (FGU-C)
Impakt faktor: 4.861, rok: 2021
Způsob publikování: Omezený přístup
http://dx.doi.org/10.1016/j.clinph.2021.04.016

Objective: Epilepsy surgery fails in > 30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively involved in seizure genesis. Methods: The directed transfer function was applied to intracranial EEG recordings and the effective connectivity was determined with a high temporal and frequency resolution. Pre-ictal network properties were compared with ictal epochs to identify regions actively generating ictal activity and discriminate them from the areas of propagation. Results: Analysis of 276 seizures from 30 patients revealed the existence of a seizure-related network reconfiguration in the gamma-band (25–170 Hz, p < 0.005) – ictogenic nodes. Unlike seizure onset zone, resecting the majority of ictogenic nodes correlated with favorable outcomes (p < 0.012). Conclusion: The prerequisite to successful epilepsy surgery is the accurate identification of brain areas from which seizures arise. We show that in FCD-related epilepsy, gamma-band network markers can reliably identify and distinguish ictogenic areas in macroelectrode recordings, improve intracranial EEG interpretation and better delineate the epileptogenic zone. Significance: Ictogenic nodes localize the critical parts of the epileptogenic tissue and increase the diagnostic yield of intracranial evaluation.
Trvalý link: http://hdl.handle.net/11104/0320660