Obesity-Induced Changes in Bone Marrow Homeostasis

0531064 - FGÚ 2021 RIV CH eng J - Článek v odborném periodiku
Beňová, Andrea - Tencerová, Michaela
Obesity-Induced Changes in Bone Marrow Homeostasis.
Frontiers in Endocrinology. Roč. 11, May 12 (2020), č. článku 294. ISSN 1664-2392. E-ISSN 1664-2392
Grant CEP: GA ČR(CZ) GA20-03586S
Institucionální podpora: RVO:67985823
Klíčová slova: bone marrow microenvironment * bone marrow mesenchymal stem cells * hematopoietic stem cells * immune responses * obesity * life-style interventions
Obor OECD: Cell biology
Impakt faktor: 5.555, rok: 2020
Způsob publikování: Open access
https://www.frontiersin.org/articles/10.3389/fendo.2020.00294/full

Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. Obesity has also shown to have a detrimental effect on bone homeostasis by altering bone marrow and hematopoietic stem cell differentiation and thus impairing bone integrity and immune cell properties. The origin of immune cells arises in the bone marrow, which has been shown to be affected with the obesogenic condition via increased cellularity and shifting differentiation and function of hematopoietic and bone marrow mesenchymal stem cells in favor of myeloid progenitors and increased bone marrow adiposity. These obesity-induced changes in the bone marrow microenvironment lead to dramatic bone marrow remodeling and compromising immune cell functions, which in turn affect systemic inflammatory conditions and regulation of whole-body metabolism. However, there is limited information on the inflammatory secretory factors creating the bone marrow microenvironment and how these factors changed during metabolic complications. This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discuss whether dietary intervention or physical activity may have beneficial effects on the bone marrow microenvironment and whole-body metabolism.
Trvalý link: http://hdl.handle.net/11104/0309814