Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring

0463864 - MBÚ 2017 RIV US eng J - Článek v odborném periodiku
Antvorskov, J.C. - Josefsen, K. - Haupt-Jorgensen, M. - Fundová, Petra - Funda, David P. - Buschard, K.
Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring.
Journal of Diabetes Research. Roč. 2016, July (2016), s. 3047574. ISSN 2314-6745. E-ISSN 2314-6753
Grant CEP: GA ČR GA15-24487S
Institucionální podpora: RVO:61388971
Klíčová slova: ISLET AUTOIMMUNITY * RISK * MICE
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 2.717, rok: 2016

Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy. Diabetes incidence in offspring was followed in each group (n = 16-27) for 310 days. Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups. Results. If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% (P < 0.0001) in the gluten-free group.
Trvalý link: http://hdl.handle.net/11104/0263058